MEASURMENT OF TUMOR UPTAKE OF 99M TC-DTPA —10B-CARBORANE COMPLEX IN BRAIN TO EVALUATE10B ABSORBED DOSE FOR NCT.
Keywords:
BNCT, NCT, label, radionuclide, area of interest, tumor uptakeAbstract
Although neutron capture therapy (NCT) is a very promising technique for the treatment of brain tumors, it is very difficult to clearly evaluate the dose absorbed by the brain tumor. This paper will show how to use nuclear medicine to evalutate the 10B dose aborbed by the brain tumor. 10B carborane gadolinium complex was labelled with 99mTc and quality contro! showed 95 % of radiochemical purity. Scinticamera can tell the Youuptake of 99mTc-DTPA - 10B-carborane complex in brain tumor by selecting area of interest on tumor, the count rate was read and divided by the activity injected. Using Youptake of 99mTc-DTPA-10B-carborane complex of the tumor in brain, dose of 10B absorbed by brain tumor can be evaluated. Nuclear medicine can be used instead of in vivo quantitation of boron using MRI only for the compound which can be labelled with suitable radionuclide. 99mTc is at the present time the most popular radionuclide for this purpose.
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Barth RF, Soloway AH, Fairchild RG, Brugger RM. Boron neutron capture therapy for cancer. Cancer 1992;70:2995-3007.
Gabel D. BSH as a boron carrier for glioma BNCT: overview and update. Advances in Neutron Capture Therapy. Elsevier Science B.V.1997;149-52.
Girard F, Nakamura H, Fukuda H, Yamamoto Y, Yoshida K. Rat tumor imaging with B-10 carborane gadolinium complex. Recent Advances in Biomedical Imaging. Elsevier Science B. V. 1997 ; 201-207.
Yamamoto Y. Hiroshi Hatanaka Lecture : Search for new tumor-seeking boron compound in Japan. Advances in Neutron Capture Therapy. Elsevier Science B.V.1997 ; 22-29.
Maisy Mn, Fogelman I. Thyroid cancer. In: Maisy MN, Britain KE, Gilley DL, eds. Clinical Nuclear Medicine. London: Chapman and Hill Ltd. 1983:222-5.
Fairchild RG, Bond VP, Current status of '°Bneutron capture therapy: enhancement of tumor dose via beam filtration and dose rate: and the effects of these parameters on minimum boron content: a theritical evaluation. Int J Radiat Oncol Biol Phys 1985;11:831-40.
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