TECHNETIUM-99M SESTAMIBI (99MTC MIBI) SINGLE-PHOTON EMISSION COMPUTERIZE TOMOGRAPHY IN THE DETECTION OF NASOPHARYNGEAL CARCINOMA
Abstract
Nasopharyngeal carcinoma is a radiosensitive tumor. Recurrence after radiotherapy is acommon cause of treatment failure. Early diagnosis and accurate identification of residual/ recurrent disease are essential for proper patient management. It is radiobiologically necessary to booster the irradiation dose or using combined therapy for the persistent tumor after the initial course of radiotherapy. CT and MRI cannot be used in the evaluation of response to therapy in NPC. Positron Emission Tomography (PET) have proved to be valuable as metabolic imaging tracer, however, their restricted availability and high cost are inherent limitations to their uses. We evaluated 99mTc MIBI in identifying primary tumor, neck node metastases, distance metastasis and recurrence of the diseased after therapy in NPC patients. The sensitivity and specificity in identifying primary tumor were 100% and 33% respectively. 99mTc MIBI scintigraphy can detect neck nodes metastasis 13 of 15 cases. One case of lung metastases and two cases of liver metastases can be detected by 99mTc MIBI scintigraphy in our study. The sensitivity and specificity in identifying recurrence or residual tumor in pre and post treatment group and post-treatment group were 100%, 80% and 100%, 60% respectively.
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