POSTOPERATIVE ADJUVANT RADIATION THERAPY IN BREAST CANCER PATIENTS WITH 10 OR MORE POSITIVE AXILLARY LYMPH NODES.
Abstract
This study was performed to analyse the outcome of postoperative adjuvant radiation therapy (RT) for breast cancer patients with10 or more involved axillary nodes receiving adjuvant chemotherapy. Seventy - five patients treated at Division of Radiation Oncology, Department of Radiology, Siriraj Faculty of Medicine from January 1978 to March 1995 were retrospectively reviewed with the median follow-up period 25 months. The overall survival and disease-free survival were 54.5 % and 25.9% respectively. Adjuvant RT significantly decreased locoregional disease-free survival but not improved distant disease-free survival or overall survival compared to those of systemic therapy alone. The role of RT on distant control in this high risk group of patients need more studies to be confirmed.
Downloads
Metrics
References
Nenoto T, Vana J, Bedwan R et al. Management and survival of female breast cancer : results of a national survey by the Americal College of Surgeon. Cancer 1980; 45: 2917-21.
Perez CA, Fields JN. Role of radiation therapy for locally advanced and inflammatory carcinoma of the breast. Oncology 1987; 1: 81-90.
Bonadonna G, Brusamolino E, Valagussa P et al. Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Eng J Med 1976;294 :405-10.
Perez CA, Taylor ME .Breast: Tis, T1 and T2 Tumors. In : Perez CA, Brady LW (eds), Principles & Practice of Oncology, 3 ed. J.B. Lippincott Co. 1997: 1269-1414.
Fowble B. Postmastectomy radiation : then and now. Oncology 1997; 11:213-31.
Overgaard M, Hansen PS, Overgaard J et al.Postoperative radiotherapy in high risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Eng J Med 1997; 337:949-55
Ragaz J, Jackson SM, Le N et al. Adjuvant radiaotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Eng J Med 1997;337: 956-62.
Diab SG, Hilsenbeck SG, MoorC et al. Radiation therapy and survival in breast cancer patients with 10 or more positive axillary lymph nodes treated with mastectomy. J Clin Oncol 1998:16:1655-60.
Jabro G, Wazer D, Erban J et al. The importance of loregional radiotherapy with conventional or high dose chemotherapy in the management of breast cancer with >=10 positive axillary nodes. Proc ASTRO 1997; 39:(abstr.2045)
Hortobagyi GN, Bazdar AU, Chaplin R et al. Lack of efficacy of adjuvant high-dose (HD) combination chemotherapy (CT) for high-risk primary breast cancer. (HRPBC: a randomised trial) .Proc ASCO 1998;17: (abstr 417).
Rodenhuis S, Richel DJ, Wall E et al. Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement. Lancet 1998; 352: 515-19
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 The ASEAN Journal of Radiology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Disclosure Forms and Copyright Agreements
All authors listed on the manuscript must complete both the electronic copyright agreement. (in the case of acceptance)
