PROGNOSTIC VALUE OF THE RATIO THYROGLOBULIN TO I-131 UPTAKE AFTER THYROIDECTOMY BEFORE ABLATIVE RADIOIODINE THERAPY IN WELL- DIFFERENTIATED THYROID CANCER
Abstract
Before I-131 treatment, serum Tg is not a reliable tumor marker since it can also be originated from remnant thyroid tissue or postsurgery trauma. We evaluated serum Tg and I-131, 24 hours uptake before the first I-131 treatment in 214 patients with welldifferentiated thyroid cancer (74 papillary/140 follicular). The highest value of the ratio serum Tg to J-131, 24 hours uptake in tumor-free patients (Group A) was 12.81 ng/ml/ %. Therefore the ratio higher than 12.81 ng/ml/% was indicative of metastasis or later recurrence. The sensitivity for lymph node metastases, distance metastases and late recurrence were 41.38%, 88.37%, 76.47%, respectively. The Tg/ I-131 uptake ratio might be used as a prognostic value for well-differentiated thyroid cancer patients after thyroidectomy and before I-131 treatment.
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Tourniaire J, Bernard MH, Ayzae L et al. Serum thyroglobulin assay after total unilateral lobectomy for differentiated thyroid carcinoma. Press Med 1990;19:1309-12.
Rasmussen NG, Hornnes PJ, Hegedus L, Feldt-Rasmussen U. Serum thyroglobulin during the menstrual cycle, during pregnancy, and post partum. Acta Endocrinol 1989;121:168-73.
Glinoer D, De Nayer P, Bourdoux P, et al. Regulation of maternal thyroid during pregnancy. J Clin Endocrine Metab 1990; 71(2):276-87.
Bayraktar M, Ergin M, Boyacioglu A, Demir S. A preliminary report of thyroglobulin release after fine needle aspiration biopsy of thyroid nodules. J Int Med Res 1990;18(3):253-5.
Tegler L, Erisson UB, Gillquist J, Lindvall R. Basal and thyrotropin-stimulated secretion rates of thyroglobulin from the human thyroid gland during surgery. Thyroid 1993; 3(3):213-7.
Kawamura S, Kishino B, Tajima K, Mashita K, Tarui S. Elevated serum thyroglobulin as a manifestation of acute haemorrhage into the thyroid gland. Clin Endocrinol 1984;20(2):213-9.
Van Herle AJ, Demeester-Mirkine N, Van Heuverswyn B, Dumont J. The effect of I-131 for diagnostic purposes on serum thyroglobulin (hTg) levels in subjects with thyroid disorders. J Endocrinol Invest 1981;4(1):107-20.
Madeddu G, Casu AR, Costanza C, et al. Serum thyroglobulin levels in the diagnosis and follow-up of subacute “painful” thyroiditis. Arch Intern Med 1985;145(2): 243-7.
Kraiem Z, Sadeh O, Blithe DL, Nisula BC. Human chorionic gonadotropin stimulates thyroid hormone secretion, iodide uptake, organification, and adenosine 3’ ,5’-monophosphate formation in cultured human thyrocytes. J Clin Endocrinol Metab 1994; 79(2):595-9.
Filetti S, Belfiore a, Amir SM, et al. The role of thyroid stimulating antibodies of Graves’ disease in differentiated thyroid cancer. N Engl J Med 1988;318(12):753- 9 Drall H,
Schwarzrock R, Lang W, et al Comparison of histology and immunohistochemistry with thyroglobulin serum level and radioiodine uptake in recurrences and metastases of differentiated thyroid carcinomas. Acta Endocrinol 1985:;108(4):504-10.
Heldin NE, Westermark B. The molecular biology of the human anaplastic thyroid carcinoma cell. Thyroidology 1991;3(3): 127-31.
Jeevanran RK, Shah DH, Sharma SM, et al. Influence of initial large dose on subsequent uptake of therapeutic radioiodine in thyroid cancer patients. Nucl Med Biol 1986;13:277-279.
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