RADIOPHARMACEUTICAL FOR IMAGING OF LIVER, GALL BLADDER AND BILIARY DUCTS (99mTC-DISIDA)
Abstract
The cholescintigraphic procedures have played a significant role in diagnosis of hepatobiliary disorder in Thailand. Especially 99mTc-DISIDA scintigrams of infants are the diagnosis procedures of choice for biliary atresia because it is difficult to diagnose by other means for examples CT and ultrasonography. The synthesis of DISIDA (2,6- diisopropylacetanilide iminodiacetic acid), was prepared successfully since 1983 at Section of Nuclear Medicine, Siriraj Hospital. The DISIDA compound was made into DISIDA instant kits by adding appropriate amount of stannous chloride. Each kit contained 10 mg of DISIDA and 0.25 mg of SnCl, 2H,O. Radiochemical purity was good at 2-4 ml of Na 99mTcO, (activity of 1 to 50 mCi) and lasted for 6 hours. The Lyophilized form of DISIDA-kit had stability not less than 1 year. No reports of unfavorable effects on patients with this product during the past 14 years.
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