RAPID TURNOVER PATTERN OF RADIOIODINE UPTAKE IN GRAVES’ DISEASE: CLINICAL CORRELATION AND THERAPY OUTCOME
Abstract
The retrospective study was designed to explore the prevalence of rapid turnover pattern (RTP) of radioiodine ('?'I) uptake in the patient with Graves’ disease, to find the possible clinical factors associated with this kind of uptake pattern and to compare the successful rate of '*'I treatment between RTP and non-rapid turnover pattern (NRTP). The subjects were Graves’ disease patients referred for the first '*'I therapy. The 3-hour uptake value > 24-hour uptake value was classified as RTP, whereas 3-hour value < 24-hour value was classified as NRTP. Of all 938 study subjects, 252 cases (26.9%) had RTP. The successful rate of RTP group was significantly lower than that of NRTP group (17.1% versus 42.7%, p < 0.001). In univariate analyses, significant associations were found between the RTP and age (p = 0.021), prior >24-month antithyroid drug treatment (p = 0.011), thyroid gland size, 3-hour and 24-hour uptake values (p < 0.001). However, multiple logistic regression analyses showed only 3- and 24-hour uptake values were the independent predictors of RTP (p < 0.001). RTP, even found in only about one-fourth of Graves’ disease patients, affects the outcome of 131I treatment. No clinical history is reliable to predict the possibility of RTP, except the 3- and 24-hour uptake values.
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