RAPID BOLUS SINGLE-VENEPUNCTURE VERSUS TRADITIONAL TWO-VENEPUNCTURE TECHNIQUE IN MODIFIED IN-VIVO RED BLOOD CELL LABELING FOR RADIONUCLIDE VENTRICULOGRAPHY: IS THE IMAGE QUALITY ADEQUATE?
Keywords:
red blood cell labeling, radionuclide ventriculography, plastic catheter, image qualityAbstract
Objective: In modified in-vivo red blood cell labeling, stannous pyrophosphate is traditionally injected through a metal needle, and a plastic catheter is used to take and re-inject the blood. This is problematic in patients with needle phobia or poor veins. To eliminate one venepuncture, the percentage labeling efficiency (% LE) of a new technique was ascertained and image quality of resting radionuclide ventriculography was compared with that of the traditional technique.
Methods: TechniqueA (n=20) included rapid injection of 20-ml diluted stannous pyrophosphate through an Optiva catheter and this retained catheter was later used for taking and reinjecting the labeled blood. Technique B used a traditional small volume of the stannous agent injected by metal needle and use of an Optiva catheter to manipulate pretinned blood and subsequently reinject it.
Results: The % LE of technique A at the time before reinjection and at the end of image acquisition was 75.0%±17.9% and 86.0%±11.4%, respectively. Mean left ventricle (LV) count, background (BG) count and LV to BG count was not significantly different between the two techniques (p = 0.414, 0.944, 0.338, respectively). Eighty and 20 percent of images were graded as good and fair quality in both groups, respectively.
Conclusions: This new technique provides a high and acceptable % LE for radionuclide ventriculography but needs only single venepuncture.
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