STRAIGHT LEG RAISING WHILE PERFORMING ”"TECHNETIUM SESTAMIBI INJECTION AT REST CAN REDUCE INFERIOR WALL ARTIFACT IN PATIENTS WITH A LOW-LIKELIHOOD OF CORONARY ARTERY DISEASE
Keywords:
artifact, coronary artery disease, low-level exercise, technetium-99m sestamibiAbstract
Inferior wall artifacts (IWA) are frequently found in 99mTc sestamibi resting myocardial perfusion imaging (MPI) ofa low-likelihood of coronary artery disease patients (LCP). Straight leg raising (SLR) relatively decreases proportion of sestamibi in the liver, so it may reduce subdiaphragmatic activity that can potentially cause [WA. Aim of the study is to investigate whether SLR while performing 99mTc sestamibi rest injection can reduce the incidence of WA.
Methods: Incidence of hot and cold IWA were compared between 72 LCP performing SLR during 99mTc sestamibi rest injection and 125 LCP without SLR. Three inferior segments from 20-segment model were used for myocardial grading.
Results: Age, sex, body weight and stress method for MPI were not significantly different between the two groups. The SLR group had a significantly higher incidence of non-artifact patients compared with the non-SLR group (18.1% versus 4.8%, P= 0.002). The SLR group also hada significantly lower incidence of hot IWA. (19.4%vs 41.6%, P= 0.002). Incidence of cold IWA were not different between the two groups (P = 0.225). Analysis of cold IWA patients showed less severe, even not significantly (P = 0.085), different, the same as artifact in the SLR group compared with the non-SLR group.
Conclusion: SLR while performing rest injection can reduce the incidence of hot IWA in LCP and may help in the detection of the lesions in the right coronary artery or left circumflex coronary territories.
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Wackers FJ, Berman DS, Maddahi J, Watson DD, Beller GA, Strauss HW, et al. Technetium -99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989; 30: 301-11.
Rehm PK, Atkins FB, Ziessman HA, Green SE, Akin EA, Fox LM, et al. Frequency of extra-cardiac activity and its effect on 99mTc-MIBI cardiac SPET interpretation. Nucl Med Commun 1996; 17: 851-6.
Germano G, Chua T, Kiat H, Areeda JS, Berman DS. A quantitative phantom analysis of artifacts due to hepatic activity in technetium -99m myocardial perfusion SPECT studies. J Nucl Med 1994; 35: 356-9.
Cramer MJ, Verzijlbergen JF, van der Wall EE, Vermeersch PH, Niemeyer MG, Zwinderman AH, et al. Comparison of adenosine and high-dose dipyridamole both combined with low-level exercise stress for 99mTc-MIBI SPET myocardial perfusion imaging. Nucl Med Commun 1996; 17:97-104.
Thomas GS, Prill NV, Majmundar H, Fabrizi RR, Thomas JJ, Hayashida C, et al. Treadmill exercise during adenosine infusion is safe, results in fewer adverse reactions, and improves myocardial perfusion image quality. J Nucl Cardiol 2000; 7: 439-46.
Samady H, Wackers FJ, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: role of simultaneous low-level treadmill exercise. J Nucl Cardiol 2002; 9: 188-96.
Braunwald E, Jones RH, Mark DB, Brown J, Brown L, Cheilin MD, et al. Diagnosing and managing unstable angina. Agency for Health Care Policy and Research. Circulation 1994; 90: 613-22.
Germano G, Kavanagh PB, Berman DS. Effect of the number of projections collected on quantitative perfusion and left ventricular ejection fraction measurements from gated myocardial perfusion single-photon emission computed tomographic images. J Nucl Cardiol 1996; 3: 395-402.
Jain D. Technetium-99m labeled myocardial perfusion imaging agents. Semin Nucl Med 1999; 29: 221-36.
Lisbona R, Dinh L, Derbekyan V, Novales-Diaz JA. Supine and prone SPECT 99mTc MIBI myocardial perfusion imaging for dipyridamole studies. Clin Nucl Med 1995; 20: 674-7.
Hayes SW, De Lorenzo A, Hachamovitch R, Dhar SC, Hsu P, Cohen I, et al. Prognostic implications of combined prone and supine acquisitions in patients with equivocal or abnormal supine myocardial perfusion SPECT. J Nucl Med 2003; 44: 1633-40.
Widmaier EP, Raff H, Strang KT, editors. Vander, Sherman, and Luciano's Human physiology: the mechanisms of body function. 9th ed. New York: McGraw-Hill, 2004.
Araujo W, DePuey EG Kamran M, Undavia M, Friedman M. Artifactual reverse distribution pattern in myocardial perfusion SPECT with technetium-99m sestamibi. J Nucl Cardiol 2000; 7: 633-8.
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