DISCORDANCE IN THE DIAGNOSIS OF OSTEOPOROSIS DUE TO PEAK BONE MINERAL DENSITY FROM DIFFERENT REFERENCES: JAPANESE AND NORTHEASTERN THAI WOMEN
Abstract
According to the WHO guideline in the diagnosis of osteoporosis, use of inappropriate reference can result in the inappropriate bone mineral classification. This study aimed to explore the difference between the prevalence of abnormally low bone mass diagnosed by using the Japanese and the northeastern Thai reference. The subjects were retrospectively recruited from women, aged 20-90 years, residing in the northeast Thailand who underwent bone mineral density (BMD) measurement at the lumbar spines and proximal femur from May 1998 to August 2000 at Srinagarind Hospital. Concordant and discordant rate in the interpretation between both criteria were reported. There were 653 subjects with 779 studies included. Higher prevalence of osteopenia and osteoporosis was observed by using T-score of the northeastern Thai population, compared with that diagnosed by the Japanese reference at almost all sites except Ward’s triangle. Concordant diagnoses were found in 73.6% of all sites. Significant diagnostic agreement between both criteria was noted at all sites (Kappa = 0.18-0.80, p <0.001). Although resulting in some discordant classification, using the northeastern Thai reference classified the same BMD status in almost three-fourths of all sites. This study stressed the limitation of the WHO diagnostic guideline regarding the effect of different reference range used.
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