Hepatobiliary Abnormalities in Pediatric and Adolescent Hemoglobin Ebeta-thalassemia Detected by Ultrasonography
Keywords:
hemoglobin Ebeta-thalassemia, hepatobiliary abnormalities, liver function test, ultrasonography, gallstoneAbstract
Background/Aims;
1. To detect hepatobiliary abnormalities in hemoglobin Ebeta-thalassemia pediatric and adolescent patients by ultrasonography
2. To identify correlation between ultrasonographic findings, serum ferritin and liver function test
Material and method: Abdominal ultrasonography serum ferritin and liver function test were performed in 64 DNA analysis proven hemoglobin Ebeta-thalassemia pediatric and adolescent patients, age ranging between 5-18 years (mean 14.1 years). Ultrasonographic parameters include: gallbladder length, width, cross section, gallstone, height of left lobe of the liver, diameter of the aorta, liver parenchymal echoes, cranio-caudal length of spleen, and splenic echoes. Liver function test includes; cholesterol, total protein, albumin, globulin, total bilirubin, direct bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (AP).
Result: Statistical analysis, using factor analysis and discriminant analysis, showed negative correlation between serum ferritin and age of the patients. Gallbladder sludge and stone correlated with splenic length and cross section of the gallbladder. Splenic parenchyma abnormality correlated with height of left lobe of the liver/aorta diameter, total protein albumin and AP and length of spleen/aorta.
Conclusion: Gallbladder hypomotility may contribute to stone formation. Total protein albumin and AP showed correlation with hepatobiliary abnormalities detected by ultrasonography. Negative correlation of serum ferritin and patient's age may be due to increased iron absorption from gastrointestinal tract in younger age.
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