DETECTION OF ACUTE CEREBRAL ISCHEMIA WITH Tc-99m APCITIDE SCINTIGRAPHY
Keywords:
stroke, platelet membrane glycoprotein (complex IIB-IITA), radionuclide imagingAbstract
The established indication of Tc-99m apcitide scintigraphy is to detect deep venous thrombosis. However, due to its mechanism of binding to GP IIb/IIla receptor on activated platelet, imaging of acute cerebral thrombosis is possible. This is a case report of acute ischemic stroke patient with right leg swelling who was referred to have Tc-99m apcitide scintigraphy for diagnosis of deep venous thrombosis. The scan showed no abnormal uptake in both legs but, interestingly, uptake in the left parieto-occipital region. This corresponds to clinical and the computer tomographic finding of acute ischemic stroke in the same area. With the use of Tc-99m apcitide scintigraphy, the area of acute cerebral ischemia and its causes can be synchronously identified. Various causes of progressing stroke may also be differentiated at the same time as well.
Downloads
Metrics
References
AcutectTM Prescribing Information
Becker RC (1996). Antiplatelet therapy. Science&Medicine July/August: 12-21
Muto P, Lastoria S, Varella P, Vergara E, Salvatore M, Morgano G, Lister-James J, Bernardy JD, Dean RT, Wencker D, Borer JS (1995) Detecting deep venous thrombosis with Technetium-99m labeled synthetic peptide P280. J Nucl Med 36(8): 1384-1391
Lister-James J, Knight LC, Maurer AH, Bush Lr, Moyer BR, Dean RT (1996) Thrombus imaging with a_technetium- 99m-labeled, activated platelet receptorbinding peptide. J Nucl Med 37(5): 775- 781
Dodd LR, Krishnamurthy GT, Kreis JM, Walsh TK , Shah JH (1996) Detection of acute deep venous thrombosis (DVT) by scintigraphy with Tc-99m P280, a synthetic peptide that binds to glycoprotein Ilb/IIla receptors on activated platelets. J Nucl Med 37(5S):95P-96P. Abstract
Weiland FL, Obranovich GT, Vande Streek PR, Carretta RF (1996) Technetium-99m P280 labeled peptide in the detection and localization of deep vein thrombosis: a prospective study in 32 cases. J Nucl Med 37(5S):294P. Abstract
Taillefer R, Therasse E, Turpin §S, Lambert R, Robillard P, Soulez G (1999) Comparison of early and delayed scintigraphy with 99mTc-Apcitide and correlation with contrast-enhanced venography in detection of acute deep vein thrombosis. J Nucl Med 40:2029-2035
Pearson DA, Lister-James, McBride WJ, Wilson DM, Martel LJ, Civitello ER, Dean RT (1996) Thrombus imaging using technetium-99m-labeled high potency GPIIb/IIIa receptor antagonists. Chemistry and initial biologic studies. J Med Chem 39(7):1372-1382
Vallabhajosula S, Weinberger J, Machac J, Lister-James J, Dean RT, Lipszye H, Patel SL, Harrington E, Harrington M (1996) Technetium-99m P280, activated platelet specific techtideTM. Phase II clinical studies in patients with carotid atherosclerosis. J Nucl Med 37:272P. Abstract
Muto P. Lastoria S, Varella P, Acampa W, Vergara E, Mainolfi C, Spaziante R, Ferone D, Bernardy JD, Salvatore M (1994) Brain tumors imaging with Tc-99m labeled synthetic peptide P280. EurJ Nucl Med 21:S198. Abstract
Lastoria S, Muto P, Varella P, Vergara E, Mainolfi C, Spaziante R, Bernardy JD, Goldsmith SJ, Salvatore M (1994) Localization of human brain tumors by Tc-99m labelled P-280 synthetic peptide. J Nucl Med 35:97P. Abstract
Dougherty JH, Jr, Levy DE, Weksler BB (1977) Platelet activation in acute cerebral ischemia. Lancet 1:821-824
Millikan CH, McDowell FH (1981) Treatment of progressing stroke. Stroke 12:397-409
Katzman R, Clasen R, Klatzo I, Meyer JS, Pappius HM, Waltz AG (1977) Report of joint committee for stroke resources IV. Brain edema in stroke. Stroke 8:512-540
Hachinski V, Norris JW (1985) The deteriorating stroke. In: Hachinski V, Norris JW (eds) The acute stroke. F.A. Davis F.A. Davis, Philadelphia, pp 123- 140
Tsuda T, Kubota M, Iwakubo A, Akiba H, Shido M, Takahashi T, Nakata T, Noto T, Tanaka S, limura O (1989) Availability of 111In-labeled platelet scintigraphy in patients with — postinfarction _ left ventricular aneurysm. Ann Nucl Med 3(1): 15-24.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 The ASEAN Journal of Radiology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Disclosure Forms and Copyright Agreements
All authors listed on the manuscript must complete both the electronic copyright agreement. (in the case of acceptance)
