Pediatric imaging of neuroblastoma-From classic to atypical

Authors

  • Michal Scolnik, M.D. Department of Radiology, Resident, Rambam Health Care Campus, Haifa, Israel. https://orcid.org/0000-0003-3750-589X
  • Luda Glozman M.D. Department of Radiology, Pediatric Radiology Unit, Resident, Rambam Health Care Campus, Haifa, Israel.
  • Noa Mandel-Shorer, M.D. Department of Pediatric Hematology-Oncology, Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel.
  • Michalle Soudack Ben-Nun M.D. Pediatric Imaging Section Head, Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Israel.
  • Anat Ilivitzki, M.D. Department of Radiology, Resident, Rambam Health Care Campus, Haifa, Israel.The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

DOI:

https://doi.org/10.46475/asean-jr.v24i2.313

Keywords:

Neuroblastoma, Imaging, Pediatric, Radiology

Abstract

Neuroblastoma (NB) is the most common extracranial solid tumour in children, accounting for approximately eight percent of paediatric cancer and fifteen percent of pediatric cancer deaths. Reaching a correct and timely diagnosis is extremely important, especially in aggressive NB. Prognosis and treatment are based on tumour biology and genetics, patient age and perhaps most importantly, disease stage. The current staging system relies heavily on imaging, and this pictorial essay provides a description of the radiological features of NB, from classic to atypical, and the modalities used to help confirm the diagnosis and staging of NB. Our aim is to provide radiologists with a comprehensive collection of presentations of NB, to help improve diagnostic accuracy and decrease time to diagnose. 

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Author Biography

Anat Ilivitzki, M.D. , Department of Radiology, Resident, Rambam Health Care Campus, Haifa, Israel.The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

Assistant Professor, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel

Department of Radiology, Rambam Health Care Campus, Haifa, Israel

References

Brisse HJ, McCarville MB, Granata C, Krug KB, Wootton-Gorges SL, Kanegawa K, et al. Guidelines for imaging and staging of neuroblastic tumors: Consensus report from the International Neuroblastoma Risk Group Project. Radiology 2011;261:243-57. doi:10.1148/radiol.11101352.

Dumba M, Jawad N, McHugh K. Neuroblastoma and nephroblastoma: A radiological review. Cancer Imaging 2015;15(5):1-14. doi:10.1186/s40644-015-0040-6.

Hwang SM, Yoo SY, Kim JH, Jeon TY. Congenital adrenal neuroblastoma with and without cystic change: Differentiating features with an emphasis on the of value of ultrasound. Am J Roentgenol 20;207:1105-11. doi:10.2214/AJR.16.16452.

Chen AM, Trout AT, Towbin AJ. A review of neuroblastoma image-defined risk factors on magnetic resonancem iaging. Pediatr Radiol 2018;48:1337-47. doi:10.1007/s00247-018-4117-9.

Tsubota S, Kadomatsu K. Origin and initiation mechanisms of neuroblastoma. Cell Tissue Res 2018;372:211-21. doi:10.1007/s00441-018-2796-z.

Menager N, Quarello E, Capelle M, Lacroze V, Coze C, De Lagausie P, et al. Prenatal diagnosis of atypical adrenal neuroblastoma with pulmonary metastases is possible: Impact on the assessment of prenatal prognosis. Diagn Interv Imaging 2012;93:632-4. doi:10.1016/j.diii.2012.03.005.

Liang WH, Federico SM, London WB, Naranjo A, Irwin MS, Volchenboum SL, et al. Tailoring Therapy for Children With Neuroblastoma on the Basis of Risk Group Classification: Past, Present, and Future. JCO Clin Cancer Inform 2020;4:895-905. doi:10.1200/cci.20.00074.

Voss SD, Reaman GH, Kaste SC, Slovis TL. The ALARA concept in pediatric oncology. Pediatr Radiol 2009;39:1142-6. doi:10.1007/s00247-009-1404-5.

Richards ML, Gundersen AE, Williams MS. Cystic neuroblastoma of infancy. J Pediatr Surg 1995;30:1354-7. doi:10.1016/0022-3468(95)90504-9.

Alshahrani MA, Bin Saeedan M, Alkhunaizan T, Aljohani IM, Azzumeea FM.. Bilateral adrenal abnormalities: imaging review of different entities. Abdom Radiol (NY) 2019 44:154-79. doi: 10.1007/s00261-018-1670-5.

Coorens THH, Farndon SJ, Mitchell TJ, Jain N, Lee S, Hubank M, et al. Lineage-independent tumors in bilateral neuroblastoma. N Engl J Med 2020;383:1860-5. doi:10.1056/NEJMoa2000962.

Hiyama E, Yokoyama T, Hiyama K, Yamaoka H, Matsuura Y, Nishimura Si, et al. Multifocal Neuroblastoma. Cancer 2000;88:1955-63.

Skiker I, Dafiri R. Synchronous primary neuroblastoma. Eurorad 2008;CASE 6594:1-7. doi:10.1594/EURORAD/CASE.6594.

Fan R. Primary Renal Neuroblastoma — A Clinical Pathologic Study of 8 Cases. Am J Surg Pathol 2012;36:94-100. doi: 10.1097/PAS.0b013e318233083b.

Morrison ZD, Sun Y, Manalang M, Dominguez K. Primary pancreatic neuroblastoma in an infant. J Pediatr Hematol Oncol 2020;42:E541-3. doi:10.1097/MPH.0000000000001629.

Galgano S, Royal S. Primary pancreatic neuroblastoma presenting with opsoclonus-myoclonus syndrome. Radiol Case Reports 2016;11:36-40. doi:10.1016/j.radcr.2015.09.003.

Caldwell NJ, Sato TS. Ectopic primary olfactory neuroblastoma of the nasopharynx: A case report and review of the literature. Radiol Case Rep 2019;14:997-1002. doi:10.1016/j.radcr.2019.05.031.

Pacino GA, Cocuzza S, Maniaci A, Da Mosto MC, Pavone P, Spinato G. Correction to: advanced olfactory neuroblastoma in a teenager: a clinical case and short review of literature. Childs Nerv Syst 2020;36:485-9. doi:10.1007/s00381-020-04566-x.

Cai JB, Wang JH, He M, Wang FL, Xiong JN, Mao JQ, et al. Unusual presentation of bladder neuroblastoma in a child: A case report. World J Clin Cases 2020;8:194-9. doi:10.12998/wjcc.v8.i1.194.

Dey S, Ghosh A, Sil K, Saha Basu K, Chatterjee U. Congenital Sacrococcygeal Neuroblastoma: A Report of Two Cases with Summary of Prior Published Cases. Fetal Pediatr Pathol 2020;41:643-50. doi:10.1080/15513815.2020.1857486.

Inazawa N, Hatakeyama N, Hori T, Yamamoto M, Igarashi K, Tadashi H, et al. Primary orbital neuroblastoma in a 1-month-old boy. Pediatr Int 2014;56:122-5. doi:10.1111/ped.12239.

Niwa Y, Yamamuro O, Kato N, Tsuzuki T. Two cases of primary ovarian neuroblastoma arising from mature cystic teratomas. Gynecol Oncol Case Rep 2013;5:58-60. doi:10.1016/j.gynor.2013.04.006.

Chalam KV, Gupta SK, Vinjamaram S, Shah VA. Clinicopathologic reports, case reports, and small case series: congenital anomalous retinal artery associated with a leaking macroaneurysm. Arch Ophthalmol 2003;121:409-10. doi: 10.1001/archopht.121.3.409.

Botía González CM, Sirvent Cerdá SI, Azorín D. Bone metastasis of primitive occult neuroblastoma. Eurorad 2018;Case 15699. doi:10.1594/EURORAD/CASE.15699.

Piccardo A, Morana G, Puntoni M, Campora S, Sorrentino S, Zucchetta P, et al. Diagnosis, Treatment Response, and Prognosis: The Role of 18 F-DOPA PET/CT in Children Affected by Neuroblastoma in Comparison with 123 I-mIBG Scan: The First Prospective Study. J Nucl Med 2020;61:367-74. doi:10.2967/jnumed.119.232553.

Kushner BH. Neuroblastoma: A Disease Requiring a Multitude of Imaging Studies. J Nucl Med 2004;45:1172-88.

Yang WJ, Zhou YY, Zhao F, Mei ZM, Li S, Xiang Y. Orbital neuroblastoma metastasis: A case report and literature review. Medicine (Baltimore) 2019;98(36):e17038. doi: 10.1097/MD.0000000000017038.

Otmani N, Khattab M. Metastatic neuroblastoma to the mandible in a 3-year-old boy: a case report. Med Oral Patol Oral Cir Bucal 2007;12(3):E201-4.

DuBois SG, London WB, Zhang Y, Matthay KK, Monclair T, Ambros PF, et al. Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer 2008;51:589-92. doi:10.1002/pbc.21684.

He B, Mao J, Huang L. Clinical Characteristics and Survival Outcomes in Neuroblastoma With Bone Metastasis Based on SEER Database Analysis. Front Oncol 2021;11:677023. doi:10.3389/fonc.2021.677023.

Kammen BF, Matthay KK, Pacharn P, Gerbing R, Brasch RC, Gooding CA. Pulmonary metastases at diagnosis of neuroblastoma in pediatric patients: CT findings and prognosis. AJR Am J Roentgenol 2001;176:755-9. doi:10.2214/ajr.176.3.1760755.

Matthay KK, Brisse H, Couanet D, Couturier J, Bénard J, Mosseri V, et al. Central nervous system metastases in neuroblastoma: Radiologic, clinical, and biologic features in 23 patients. Cancer 2003;98:155-65. doi:10.1002/cncr.11448.

Sakai S, Nomura K, Abe T, Hayashi K, Tsutsuno T, Mizushima H, et al. Neuroblastoma with ovarian and pancreatic metastasis. J Pediatr Surg Case Reports 2021;73:e101996. doi:10.1016/j.epsc.2021.101996.

Kumar R, Vankadari K, Mittal BR, Bansal D, Trehan A, Sahu JK, et al. Diagnostic values of 68Ga-labelled DOTANOC PET/CT imaging in pediatric patients presenting with paraneoplastic opsoclonus myoclonus ataxia syndrome. Eur Radiol 2021;31:4587-94. doi:10.1007/s00330-020-07587-x.

Bhatia P, Heim J, Cornejo P, Kane L, Santiago J, Kruer MC. Opsoclonus-myoclonus-ataxia syndrome in children. J Neurol 2022;269:750-7. doi:10.1007/s00415-021-10536-3.

Anand S, Agarwala S, Jain V, Bakhshi S, Dhua A, Gulati S, et al. Neuroblastoma with Opsoclonus-Myoclonus-Ataxia Syndrome: Role of Chemotherapy in the Management: Experience from a Tertiary Care Center in a Resource-limited Setting. J Pediatr Hematol Oncol 2021;43:E924-E929. doi:10.1097/MPH.0000000000002131.

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Published

2023-08-31

How to Cite

1.
Scolnik M, Glozman L, Mandel-Shorer N, Soudack Ben-Nun M, Ilivitzki A. Pediatric imaging of neuroblastoma-From classic to atypical. ASEAN J Radiol [Internet]. 2023 Aug. 31 [cited 2024 Nov. 23];24(2):155-79. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/313

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Pictorial Essay

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