Calcific uraemic arteriolopathy: A rare but devastating complication of end-stage renal failure

Authors

  • Pak Lun LAM, FRCR Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital,Hong Kong.
  • Chi Hin CHAN, FHKAM Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital,Hong Kong.
  • Dicken WONG, FRCR Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital,Hong Kong.
  • Kwan Shun NG, FHKAM Department of Pathology, Kwong Wah Hospital, Hong Kong.
  • Danny Hing Yan CHO, FHKAM Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital,Hong Kong.

DOI:

https://doi.org/10.46475/asean-jr.v25i2.897

Keywords:

calcific uraemic arteriolopathy, calciphylaxis, renal failure

Abstract

Calcific uraemic arteriolopathy is a rare complication of end-stage renal failure. It has a grave prognosis with 1-year survival of under 50%. It occurs due to subcutaneous small vessel calcification, thrombosis, with subsequent tissue necrosis.

 

Calcific uraemic arteriolopathy is a rare complication of end-stage renal failure. It carries a grave prognosis with 1-year survival of under 50%. It occurs due to subcutaneous small vessel calcification, thrombosis, with subsequent tissue necrosis.

 

We described a case of calcific uraemic arteriolopathy in a 58-year-old man who presented with violaceous indurations over bilateral lower limbs, as well as large necrotic ulcer with adjacent eschars at the lower abdomen. Although skin biopsy is the gold standard for diagnosis, it is often avoided due to potential poor wound healing. On the other hand, in radiographs or computed tomography, fine linear or serpiginous subcutaneous calcifications are typical manifestations, which represent underlying small vessel calcifications. Radiological examinations, therefore, play an important role to establish the diagnosis.

 

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Colboc H, Moguelet P, Bazin D, Carvalho P, Dillies AS, Chaby G, et al. Localization, morphologic features, and chemical composition of calciphylaxis-related skin deposits in patients with calcific uremic arteriolopathy. JAMA Dermatol 2019;155:789-96. doi: 10.1001/jamadermatol.2019.0381.

Weenig RH, Sewell LD, Davis MD, McCarthy JT, Pittelkow MR. Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol 2007;56:569-79. doi: 10.1016/j.jaad.2006.08.065.

Jovanovich A, Chonchol M. Calcific uremic arteriolopathy revisited. J Am Soc Nephrol 2016;27:3233-5. doi: 10.1681/ASN.2016040480.

Jeong HS, Dominguez AR. Calciphylaxis: controversies in pathogenesis, diagnosis and treatment. Am J Med Sci 2016;351:217-27. doi: 10.1016/j.amjms.2015.11.015.

Bleibel W, Hazar B, Herman R. A case report comparing various radiological tests in the diagnosis of calcific uremic arteriolopathy. Am J Kidney Dis 2006;48:659-61. doi: 10.1053/j.ajkd.2006.05.031.

Downloads

Published

2024-09-02

How to Cite

1.
Lam PL, Chan CH, Wong D, Ng KS, Cho DHY. Calcific uraemic arteriolopathy: A rare but devastating complication of end-stage renal failure. ASEAN J Radiol [Internet]. 2024 Sep. 2 [cited 2024 Dec. 12];25(2):163-72. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/897

Issue

Section

Classic Case

Similar Articles

<< < 1 2 3 4 5 6 

You may also start an advanced similarity search for this article.