Renal complication of crizotinib: Crizotinib-associated complex renal cyst


  • Warissara Jutidamrongphan, M.D. The Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
  • Pimporn Puttawibul, M.D. The Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand



Crizotinib, Non-small cell lung cancer, Complex renal cyst, ALK inhibitor.


Crizotinib is one of the first generations of tyrosine kinase inhibitors targeting anaplastic lymphoma kinase(ALK) and is recently found to be associated with the development of complex renal cysts with inconclusive explanation up to this time. Hereby, we discuss the hypothesis of Crizotinib-associated complex renal cyst development and coexisting renal impairment after initiation of the treatment in a 75-year-old man with ALK-positive non-small cell lung cancer whose complex renal cysts evolved after initiation and cessation of Crizotinib treatment. The coexistence as renal impairment persisted even after switching from Crizotinib to Ceritinib.


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How to Cite

Jutidamrongphan W, Puttawibul P. Renal complication of crizotinib: Crizotinib-associated complex renal cyst. ASEAN J Radiol [Internet]. 2020Mar.16 [cited 2023Oct.4];21(1):44-56. Available from:



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