DOSE CALCULATION USING 4 HOUR I-131 UPTAKE FOR RETREATMENT RADIOIODINE THERAPY OF PATIENTS WITH GRAVES’ DISEASE
Keywords:
radionuclide therapy, 131 I, hyperthyroidism, Graves’disease, Thyroid uptakeAbstract
Objective: The purpose of this study is to evaluate the feasibility of using the 4 hour 131I uptake value in the calculation of treatment dose of radioiodine for the patients previously treated by 131I for hyperthyroidism but still having persistent symptoms. This would permit uptake measurement and therapy within the same day,thus reducing the cost and inconvenience to the patient.
Subject: One hundred and sixty Graves’disease patients who were previously treated with 131I but remain hyperthyroid are included in this study.
Method: The patients were randomly devided into 2 groups. First group was used to develop a regression relationship between 4 hr. and 24 hr 131I uptake. The second group was used to calculate the predicted therapeutic dose of 131l, which was calculated from 4 hr. 131I uptake.
Result: Correlation between 4 hr. and 24 hr. 131 I uptake is high (r= 0.71). These data allow us to develop a linear regression equation ;24 hr. 131 I uptake = 36.764 + 0.518 (4 hr. 131 I uptake ). The predicted therapeutic doses calculation using 4 hr. 131] uptake, correlate well with the calculated doses, base on the actual 24 hr. 131I uptake (r = 0.92).
Conclusion: There is a high correlation in the predicted dose derived by calculation using 4 hr 131I uptake and the actual doses calculated by using 24 hr. = uptake. Therefore, the 4 hr. 131I uptake value can be used to calculate the treatment doses of radioiodine for the previously treated patients who still have persistent hyperthyroidism
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