Correlation between shear wave elastography and vibration-controlled transient elastography of liver stiffness in chronic hepatitis B infection in Samut Sakhon Hospital


  • Yasinee Mekavuthikul, M.D. Department of Diagnostic Radiology, Samut Sakhon Hospital, Samut Sakhon, Thailand.
  • Lakkana Jirapong, M.D. Department of Diagnostic Radiology, Samut Sakhon Hospital, Samut Sakhon, Thailand.
  • Orawan Autravisittikul, M.D. Department of Diagnostic Radiology, Samut Sakhon Hospital, Samut Sakhon, Thailand.



2D shear wave elastography (2D-SWE), Vibration-controlled transient elastography (VCTE), Liver fibrosis


Background: Assessment of the liver stiffness to evaluate liver fibrosis in viral hepatitis has been an important factor in the management guideline. Due to limitations of liver biopsy, non-invasive assessments of liver stiffness become a more practical method. Vibration-controlled transient elastography (VCTE) has been widely used for a long time and the newcomer, 2D shear wave elastography (2D-SWE) was claimed to possess a strong correlation.

Objective: To assess agreement and correlation of liver stiffness measurement using VCTE and 2D-SWE in patients with viral hepatitis B.

Materials and Methods: 34 patients with a laboratory confirmation as viral hepatitis infected were included. Liver stiffness measurements were obtained using 2D-SWE with VCTE serving as the reference standard on the same occasion. The differences of two measurements were demonstrated by both Bland-Altman and scattered plot. We analyzed their mean differences, 95% limit of agreement, and Spearman correlation (rs) coefficient to determine the agreement and the correlation of the 2D-SWE compared to VCTE.

Results: For VCTE and 2D-SWE, the median elasticity was 5.35 kPa (IQR 4.57, 6.77) and 6.90 kPa (IQR 6.07, 8.25), respectively. The mean differences of the elasticity of tissue between VCTE and SWE were 0.50 kPa (S.D. 3.25 kPa) and 95% limit of agreement was between -6.87 and 5.87 kPa. There was a strong correlation (rs =0.659) between VCTE and 2D-SWE.

Conclusion: In this pilot experience of these two methods, the initial correlation test in real clinical setting has proved a strong measurement correlation between Shear wave elastography and VCTE in hepatitis B patients. 



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Somboon K, Siramolpiwat S, Vilaichone RK. Epidemiology and survival of hepatocellular carcinoma in the central region of Thailand. Asian Pac J Cancer Prev 2014;15:3567-70. doi: 10.7314/apjcp.2014.15.8.3567.

Bruix J, Sherman M; Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology 2005;42:1208-36. doi: 10.1002/hep.20933.

Jung KS, Kim SU, Ahn SH, Park YN, Kim DY, Park JY, et al. Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan). Hepatology 2011;53:885-94. doi: 10.1002/hep.24121.

Chitapanarux T, Phornphutkul K. Risk factors for the development of hepatocellular carcinoma in Thailand. J Clin Transl Hepatol 2015;3:182-8. doi: 10.14218/JCTH.2015.00025.

Virani S, Bilheem S, Chansaard W, Chitapanarux I, Daoprasert K, Khuanchana S, et al. National and subnational pPopulation-based incidence of cancer in Thailand: Assessing cancers with the highest burdens. Cancers (Basel) 2017;9:108. doi: 10.3390/cancers9080108.

El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012;142:1264-73 e1. doi: 10.1053/j.gastro.2011.12.061.

Alqahtani SA, Colombo M. Viral hepatitis as a risk factor for the development of hepatocellular carcinoma. Hepatoma Res [Internet] 2020 [cited 2022 Aug 18];6:58. Available from: http://7b74039fde63b1e554e618a61665d60891d0.pdf

Di Bisceglie AM. Hepatitis B and hepatocellular carcinoma. Hepatology 2009;49(5 Suppl):S56-60. doi: 10.1002/hep.22962.

Kim JH, Kim MN, Han KH, Kim SU. Clinical application of transient elastography in patients with chronic viral hepatitis receiving antiviral treatment. Liver Int 2015;35:1103-15. doi: 10.1111/liv.12628.

Huang R, Jiang N, Yang R, Geng X, Lin J, Xu G, et al. Fibroscan improves the diagnosis sensitivity of liver fibrosis in patients with chronic hepatitis B. Exp Ther Med 2016;11:1673-7. doi: 10.3892/etm.2016.3135.

O'Hara S, Hodson S, Hernaman C, Wambeek N, Olynyk J. Concordance of transient elastography and shear wave elastography for measurement of liver stiffness. Sonography [Internet] 2017 [cited 2022 Aug 18];4:141-5. Available from:

Castera L, Forns X, Alberti A. Non-invasive evaluation of liver fibrosis using transient elastography. J Hepatol 2008;48:835-47. doi: 10.1016/j.jhep.2008.02.008.

Rockey DC, Bissell DM. Noninvasive measures of liver fibrosis. Hepatology 2006;43(2 Suppl 1):S113-20. doi: 10.1002/hep.21046.

Castera L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M, et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 2005;128:343-50. doi: 10.1053/j.gastro.2004.11.018.

Masuzaki R, Tateishi R, Yoshida H, Goto E, Sato T, Ohki T, et al. Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography. Hepatology 2009;49:1954-61. doi: 10.1002/hep.22870.

Ganne-Carrie N, Ziol M, de Ledinghen V, Douvin C, Marcellin P, Castera L, et al. Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases. Hepatology 2006;44:1511-7. doi: 10.1002/hep.21420.

Foucher J, Chanteloup E, Vergniol J, Castera L, Le Bail B, Adhoute X, et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 2006;55:403-8. doi: 10.1136/gut.2005.069153.

Kim DY, Kim SU, Ahn SH, Park JY, Lee JM, Park YN, et al. Usefulness of FibroScan for detection of early compensated liver cirrhosis in chronic hepatitis B. Dig Dis Sci 2009;54:1758-63. doi: 10.1007/s10620-008-0541-2.

Wei H, Jiang HY, Li M, Zhang T, Song B. Two-dimensional shear wave elastography for significant liver fibrosis in patients with chronic hepatitis B: A systematic review and meta-analysis. Eur J Radiol 2020;124:108839. doi: 10.1016/j.ejrad.2020.108839.

Fu J, Wu B, Wu H, Lin F, Deng W. Accuracy of real-time shear wave elastography in staging hepatic fibrosis: a meta-analysis. BMC Med Imaging 2020;20(1):16. doi: 10.1186/s12880-020-0414-5.

Wong VW, Vergniol J, Wong GL, Foucher J, Chan HL, Le Bail B, et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 2010;51:454-62. doi: 10.1002/hep.23312.

Ferraioli G, Maiocchi L, Dellafiore C, Tinelli C, Above E, Filice C. Performance and cutoffs for liver fibrosis staging of a two-dimensional shear wave elastography technique. Eur J Gastroenterol Hepatol 2021;33:89-95. doi: 10.1097/MEG.0000000000001702.

Noola B, Thongprateep K, Chirapongsatorn S, Saengruang-Orn S. Correlation of liver stiffness in chronic liver disease between fibroscan and 2D shear wave elastography in Phramongkutklao hospital. J Southeast Asian Med Res [Internet] 2019 [cited 2022 Aug 18];3:67-72. Available from:

Bende F, Sporea I, Sirli R, Popescu A, Mare R, Miutescu B, et al. Performance of 2D-SWE.GE for predicting different stages of liver fibrosis, using transient elastography as the reference method. Med Ultrason 2017;19:143-9. doi: 10.11152/mu-910.




How to Cite

Mekavuthikul Y, Jirapong L, Autravisittikul O. Correlation between shear wave elastography and vibration-controlled transient elastography of liver stiffness in chronic hepatitis B infection in Samut Sakhon Hospital. ASEAN J Radiol [Internet]. 2022 Aug. 31 [cited 2024 Jun. 13];23(2):73-88. Available from:



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