CONCURRENT CHEMO-RADIOTHERAPY FOR LIVER METASTASIS FROM BREAST CANCER: TWO CASES REPORT
Keywords:
Breast Cancer, Liver metastasis, Concurrent chemo-radiotherapyAbstract
Two cases of multiple liver metastases from breast cancer, failed to the previous chemotherapy, were treated with concurrent chemo-radiotherapy. Thirty Grays of external irradiation was given to the whole liver in 3 weeks and 300 mg/m2BSA of carboplatin on day 1 and 750 mg/m2BSA of 5FU from day 1 to day 4 were also combinely given. After then, chemotherapy of the same regimen were repeated every four weeks. The tumor showed good response within 1-2 months after treatment. The metastatic areas in the liver were replaced with regenerating nodules in one case at one and a half year later. The patients could tolaterate the treatment very well without any complications, both clinicals and liver function test. Concurrent chemo-radiotherapy might be an alternative treatment for metatstatic breast cancer to the liver.
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Concurrent chemo-radiation therapy is an alternative treatment for liver metastasis from breast
cancer.
Radiation dose of 30 Gy may be the optimal dose for whole liver irradiation with no acute and late complications.
Carboplatin and 5FU might be a good radiosensitizer and also a candidate for palliative chemotherapeutic agent for metastatic breast cancer.
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