Sonographic findings of recurrent disease at the thyroid bed in differentiated thyroid cancer

Authors

  • Pinyaporn On-Ekkasit Hatyai hospital
  • Sorasich Subhadhirasakul Department of radiology, Hatyai Hospital, Songkhla, Thailand
  • Jalat Busaman Department of radiology, Hatyai Hospital, Songkhla, Thailand
  • Songklod Pakdeejit Department of radiology, Hatyai Hospital, Songkhla, Thailand

DOI:

https://doi.org/10.46475/asean-jr.v25i3.902

Keywords:

Sonographic findings, thyroid cancer, recurrent disease, thyroid bed

Abstract

Background: Neck ultrasonography (US) is an important tool for evaluating the response to therapy of differentiated thyroid cancer (DTC) and surveillance of a possible disease recurrence.

Objective: To evaluate sonographic findings associated with recurrent disease at the thyroid bed in patients with DTC.

Materials and methods: This was a retrospective cohort study. We reviewed the data of 26 patients with DTC who underwent thyroidectomy and had thyroid bed lesions detected by neck US between January 2016 and December 2023. Sonographic findings of recurrent and non-recurrent lesions were compared.

Results: A total of 26 thyroid bed lesions in 26 patients were identified, including 17 recurrent and nine non-recurrent lesions. The median size was 1.0 centimeters. Sonographic findings of recurrent versus non-recurrent lesions were hypoechoic in 58.8% versus 55.6%, wider-than-tall in 64.7% versus 100%, smooth margins in 82.4% versus 66.7%, and no calcification in 70.6% versus 88.9%. There was no significant difference in sonographic findings between recurrent and non-recurrent lesions. All 13 patients who had recurrent lesions with available laboratory results had elevated serum Tg and/or TgAb levels.

Conclusion: The sonographic findings alone could not distinguish the recurrent from non-recurrent lesions at the thyroid bed in patients with DTC. Clinical and laboratory results should be correlated to determine the need for further investigations.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2016;26:1-133.

Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet 2016;388:2783–95.

Schlumberger MJ. Papillary and follicular thyroid carcinoma. N Engl J Med 1998;338:297-306.

Mettler FA, Guiberteau MJ. Essentials of nuclear medicine and molecular imaging. 7th ed. Philadelphia, PA: Elsevier; 2019.

Mazzaferri EL. An overview of the management of papillary and follicular thyroid carcinoma. Thyroid 1999;9:421-7.

Frasoldati A, Pesenti M, Gallo M, Caroggio A, Salvo D, Valcavi R. Diagnosis of neck recurrences in patients with differentiated thyroid carcinoma. Cancer 2003;97:90–96.

Rondeau G, Fish S, Hann LE, Fagin JA, Tuttle RM. Ultrasonographically detected small thyroid bed nodules identified after total thyroidectomy for differentiated thyroid cancer seldom show clinically significant structural progression. Thyroid 2011;21:845–53.

Shin JH, Han BK, Ko EY, Kang SS. Sonographic findings in the surgical bed after thyroidectomy: comparison of recurrent tumors and nonrecurrent lesions. J Ultrasound Med 2007;26:1359–66.

Lee JH, Lee HK, Lee DH, Choi CG, Gong G, Shong YK, et al. Ultrasonographic findings of a newly detected nodule on the thyroid bed in postoperative patients for thyroid carcinoma: correlation with the results of ultrasonography-guided fine-needle aspiration biopsy. Clin Imaging 2007;31:109-13.

Ko MS, Lee JH, Shong YK, Gong GY, Baek JH. Normal and abnormal sonographic findings at the thyroidectomy sites in postoperative patients with thyroid malignancy. AJR 2010;194:1596–609.

Kamaya A, Gross M, Akatsu H, Jeffrey RB. Recurrence in the thyroidectomy bed: sonographic findings. AJR 2011;196:66–70.

Leenhardt L, Erdogan MF, Hegedus L, Mandel SJ, Paschke R, Rago T, et al. 2013 European thyroid association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur Thyroid J 2013;2:147–59.

Tessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Berland SA, et al. ACR thyroid imaging, reporting and data system (TI-RADS): White paper of the ACR TI-RADS committee. J Am Coll Radiol 2017;14:587-95.

Downloads

Published

2025-01-01

How to Cite

1.
On-Ekkasit P, Subhadhirasakul S, Busaman J, Pakdeejit S. Sonographic findings of recurrent disease at the thyroid bed in differentiated thyroid cancer. ASEAN J Radiol [Internet]. 2025 Jan. 1 [cited 2025 Jan. 22];25(3):219-32. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/902

Issue

Section

Original Article

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.