SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS IN THALASSEMIA: EFFECTIVE RESULTS OF RADIOTHERAPY: A REPORT OF TWO PATIENTS AND REVIEW OF THE LITERATURE

Authors

  • Titaree SUWANNALAI Department of Radiology Naresuan University

Keywords:

Spinal cord compression, Extramedullary hematopoiesis, Thalassemia, Radiation therapy

Abstract

Spinal cord compression due to extramedullary hematopoiesis is a rare complication in patients with thalassemia. Radiation therapy is one of the effective modalities of treatment. This is a report of two patients with thalassemia who had different degrees of paraplegia due to spinal cord compression from extramedullary hematopoietic tissues. The neurological symptoms relived after radiotherapy. The results confirm the role of radiation therapy as an effective treatment for this complication.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Parsa K, Oreizy A. Nonsurgical approach to paraparesis due to extramedullary hematopoiesis. Report of two cases. J Neurosurg 1995; 82: 657-660.

Oustwani MB, Kurtides ES, Chirst M, Circ I. Spinal cord compression with paraplegia in myelofibrosis. Arch Neurol 1980; 37: 389-390.

Papavasiliou C, Sandilos P. Effect of radiotherapy in symptoms due to heterotopic marrow in beta-thalassemia. Lancet 1987; 1: 13-14.

Verani R, Olson J, Moake JL. Intrathoracic extramedullary hematopoiesis: report of a case in a patient with sickle-cell disease-beta -thalassemia. Am J Clin Pathol. 1980 Jan; 73 (1): 133-7.

Drevet D, Champion M, Joffre P, Jakubowicz B. [Thoracic extramedullary hematopoiesis. Apropos of a case]. Ann Radiol (Paris). 1991; 34(6-7):393-7. Review.

Yu YC, Kao EL, Chou SH, Lin TJ, Chien CH. Intrathoracic extramedullary hematopoiesis simulating posterior mediastinal mass--report of a case in patient with beta-thalassemia intermedia. Gaoxiong Yi Xue Ke Xue Za Zhi. 1991 Jan; 7(1): 43-8. Review.

Moran CA, Suster S, Fishback N, Koss MN., Extramedullary hematopoiesis presenting as posterior mediastinal mass: a study of four cases. Boyacigil S, Ardic S, Tokoglu F, Pasaoglu E, Karakas HM. Intrathoracic extramedullary haemopoiesis. Australas Radiol. 1996 May; 40(2): 179-81.

Loh CK, Alcorta C, McElhinney AJ. Extrameduulary hematopoiesis simulating posterior mediastinal tumors. Ann Thorac Surg. 1996 Mar; 61(3): 1003-5.

El Bahri-Ben Mrad F, Zaouachi N, Fredj M, Ben Mrad S, Mrabet A. [A new case report of spinal cord compression secondary to beta -thalassemia]. Rev Neurol (Paris). 2003 May; 159(5 Pt 1): 574-6.

Castelli R, Graziadei G, Karimi M, Cappellini MD. Intrathoracic masses due to extramedullary hematopoiesis. Am J Med Sci. 2004 Nov; 328(5): 299-303.

Mutijima E, Hmissa S, Ziadi S, Mlaiki A, Mokni M, Korbi S. [Cord compression secondary to extramedullary hematopoiesis in a patient with beta-thalassaemia]. Rev Med Liege. 2005 Jan; 60(1): 41-4.

Abbassioun K, Amir-Jamshidi A. Curable paraplegia due to extradural hematopoietic tissue in thalassemia. Neurosurgery 1982; 11: 804-807.

Coraddu M, Floris F, Meleddu V, Nurchi GC, Cacace E, Contini R, Perpignano G. [Spinal cord and cauda equina compression in 2 patients with beta-thalassemia intermedia] Neurochirurgie. 1991; 37(1): 58-60.

da Fonseca SF, Figueiredo MS, Cancado RD, Nakandakare F, Segreto R, Kerbauy J. Spinal cord compression in beta-thalassemia: follow -up after radiotherapy. Sao Paulo Med J. 1998 Nov-Dec; 116(6): 1879-81.

Martinez-Rodrigo MA, Sanjuanbenito L, Rodriguez del Barrio E, Martinez-San Millan J, Saldana D. [Spinal cord compression secondary to epidural extramedullary hematopoiesis in thalassemia: a clinical case and review of literature] Rev Neurol. 1998 Dec; 27(160): 998-1004. Review.

Bruneteau G, Fenelon G, Khalil A, Kanfer A, Girot R. [Spinal cord compression secondary to extramedullary hematopoiesis in a patient with thalassemia] Rev Neurol (Paris). 2000 May; 156(5): 510-3.

Niggemann P, Krings T, Hans F, Thron A. Fifteen-year follow-up of a patient with beta thalassaemia and extramedullary haematopoietic tissue compressing the spinal cord. Neuroradiology. 2005 Apr; 47(4): 263-6. Epub 2005 Apr 6.

Jasvinder P.S. Chawla, Paul Grindstaff, Behrooz Azar-Kila, Sucha Nand. Extramedullary hematopoiesis in Thalassemia with paraparesis. Clin Pract Rev, 2004: 340-344

Tze-Ching Tan FRCS, Joanne Tsao FRCR, Fung-Ching Cheung FRCS. Extramedullary haemopoiesis in thalassemia intermedia presenting as paraplegia. Journal of Clinical Neuroscience 2002; 9(6): 721-725

Issaragrisil S., PianKiJagum A., Wasi P. Spinal cord compression in thalassemia: report of 12 cases and recommendation of treatment. Arch of Int Med 1981; 141: 1033-1036.

Turgut B, Pamuk GE, Vural O et al. An interesting presentation of intrathoracic extramedullary hematopoiesis in a patient with thalassemia intermedia. Clin Lab Haem 2003; 25: 409-12.

I Gatto, V Terrana and L Biondi, Compressione sul midollo spinale da proliferazione di midollo osseo spazio epidurale in sogetto affetto da malattia di Cooley splenectomizato. Haematologica 38 (1954), pp. 61-76.

Mann KS, Yue CP, Chan KH, Ma LT, Ngan H. Paraplegia due to extramedullary hematopoiesis in thalassemia. Case report. J Neurosurg 1987; 66: 938-940.

David CV, Balasubramaniam P. Paraplegia with thalassemia. Aust NZJ Surg 1983; 53: 283-284

A Amirjamshidi, K Abbassioun and S E Ketabchi , Spinal extradural hematopoiesis in adolescents with thalassemia. Report of two cases and a review of the literature. Childs Nerv Syst 7 (1991), pp. 223-225.

Lau S.K., Chan C.K. et Chow Y.Y.N. Cord compression due to extramedullary haematopoiesis in a patient with thalassemia. Spine, 1994; 19 (21): 2467-2470.

S Prabhakar, J S Chopra, V K Khosla, S Dash and A K Banerjee, Spinal cord compression in homozygous beta thalassemia. Surg Neurol 13 (1980), pp. 351-354.

E G Singounas, D E Sakas and D M Hadley, Paraplegia in a pregnant thalassemic woman due to extramedullary hematopoiesis: successful management with transfusions. Surg Neurol 36 (1991), pp. 210-215.

S Singhal, S Sharma and D Dixit , The role of radiation therapy in the management of spinal cord compression due to extramedullary hematopoiesis in thalassemia. J Neurol Neurosurg Psychiatry 55 (1992), pp. 310-312.

WF Luitjes, R Braakman and J Abels , Spinal cord compression in a new homozygous variant of beta-thalassemia. Case report. J Neurosurg 57 (1982), pp. 846-848.

W Luyendjik, L Went and H D Schaad, Spinal cord compression due to extramedullary hematopoiesis in homozygous thalassemia: case report. J Neurosurg 42 (1975), pp. 212- 216.

T Kaufmann, M Coleman, P Giardina and L ZNisce , The role of radiation therapy in the management of hematopoietic neurologic complications in thalassemia. Acta Haematol 85 (1991), pp. 156-159.

E Cos, kun, A Keskin, T Suzer, Y Sermez, T Kildaci and K Tahta , Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia. Eur Spine J1998; 7: 501-504.

V Phupong, B Uerpairojkij and S Limpongsanurak, Spinal cord compression: a rareness in pregnant thalassemic woman. J Obstet Gynaecol Res 26 (2000), pp. 117-120. P

Mancuso, A Zingale, L Basile, I Chiaramonte and R Tropea , Cauda equina compression syndrome in a patient affected by thalassemia intermedia: complete regression with blood transfusion therapy. Childs Nerv Syst 9 (1993), pp. 440-441.

H Hassoun, L Lawn-Tsao, E R Langevin, E S Lathi and J Palek , Spinal cord compression secondary to extramedullary hematopoiesis: a noninvasive management based on MRI. Am J Hematol 37 (1991), pp. 201-203.

D V Jackson, Jr, M E Randall and F Richards, 2nd, Spinal cord compression due to extramedullary hematopoiesis in thalassemia: long-term follow-up after radiotherapy. Surg Neurol 29 (1988), pp. 389-392.

J L Da Costa, Y S Loh and E Hanam, Extramedullary hematopoiesis with multiple tumour-simulating mediastinal masses in hemoglobin E-thalassemia disease. Chest 65 (1974), pp. 210-212.

Papavasiliou C, Gouliamos A, Vlahos L, Trakadas S, Kalovidouris A, Pouliades G. CT and MRI of symptomatic spinal involvement by extramedullary haemopoiesis. Clin Radiol. 1990 Aug; 42(2): 91-2.

Aydingoz U, Oto A, Cila A. Spinal cord compression due to epidural extramedullary haematopoiesis in thalassaemia: MRI. Neuroradiology. 1997 Dec; 39(12):870-2.

Chourmouzi D, Pistevou-Gompaki K, Plataniotis G, Skaragas G, Papadopoulos L, Drevelegas A. MRI findings of extramedullary haemopoiesis. Eur Radiol. 2001; 11(9): 1803-6.

Rey J, Gagliano R, Christides C, Pillard E, Magnan F, Tourniaire P, Arwidson I, Raymond-Gelle MC, Boulat O, Arlaud J. [Spinal cord compression caused by extramedullary hematopoiesis foci in the course of thalassemia] Presse Med. 2001 Sep 29; 30(27): 1351-3.

A Guermazi, Y Miaux and J Chiras, Imaging of spinal cord compression due to thoracic extramedullary haematopoiesis in myelofibrosis. Neuroradiology 39 (1997), pp. 733-736.

Cario H, Wegener M, Debatin KM, Kohne E. Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis. Ann Hematol. 2002 Aug; 81(8): 478-82.

Epub 2002 Aug 15. Perla Vicari, Maria Stella Figueiredo. Regression of extramedullary hematopoiesis with hydroxyurea therapy in 8-thalassemia intermedia. Rev. bras. Hematol. Hemoter: 2006; 28(1): 71-72.

Konstantopoulos K., Vagiopoulos G. et al. A case of spinal cord compression by extramedullary haematopoiesis in a thalassaemic patient: A putative role for hydroxyurea- Haematologica, 1992 77: 352- 354.

Shin K. H., Sharma S. et al. Combined radiotherapeutic and surgical management of a spinal cord compression by extramedullary haematopoiesis in apatient with hemoglobine E beta-thalassemia. Acta Haematol; 1994, 91: 154-157.

Ibrahim AV, Ibrahim EM, Mitry NM, Abdul-Satir A, Kuppa A. Spinal cord compression due to intrathoracic extramedullary haematopoiesis in homozygous thalassaemia. J Neurol Neurosurg Psychiatry. 1983 Aug; 46(8): 780-2.

Salehi SA, Koski T, Ondra SL. Spinal cord compression in beta-thalassemia: case report and review of the literature. Spinal Cord. 2004 Feb; 42(2): 117-23. Review.

Sule PEKER, Mehmet CELEBISOY, Ismail AKKOL, Hamdi BEZIRCIOGLU. Paraplegia Due to Extramedullary Hematopoiesis in the Thalassemia Intermedia. Turk J Med Sci 33(2003): 341-344.

Chehal A, Aoun E, Koussa S, Skoury H, Koussa S, Taher A. Hypertransfusion: a successful method of treatment in thalassemia intermedia patients with spinal cord compression secondary to extramedullary hematopoiesis. Spine 2003 Jul 1; 28 (13) E245-9.

Mancuso P, Zingale A, Basile L, Chiaramonte I, Tropea R. Cauda equina compression syndrome ina patient affected by thalassemia intermedia: complete regression with blood transfusion therapy. Childs Nerv Syst. 1993 Nov; 9(7): 440-41.

Massenkeil G, Wichmann W, Krummenacher F, Rhyner K. [Reversible spinal cord compression caused by extramedullary hematopoietic foci in thalassemia] Dtsch Med Wochenschr. 1993 Jan 29; 118(4): 100-6.

Lee AC, Chiu W, Tai KS, Wong V, Peh WC, Lau YL. Hypertransfusion for spinal cord compression secondary to extramedullary hematopoiesis. Pediatr Hematol Oncol. 1996 Jan-Feb; 13(1): 89-94.

Tai SM, Chan JS, Ha SY, Young BW, Chan MS. Successful treatment of spinal cord compression secondary to extramedullary hematopoietic mass by hypertransfusion in a patient with thalassemia major. Pediatr Hematol Oncol. 2006 Jun; 23(4): 317-21.

Pantongrag-Brown L, Suwanwela N. Case report: chronic spinal cord compression from extramedullary haematopoiesis in thalassemia -MRI findings. Clin Radiol 1992; 46: 281-283.

Cook G., Sharp R.A. Spinal cord compression due to extramedullary haematopoiesis in myelofibrosis. J Clin Pathol 1994; 47: 464-465.

Rita K. Munn, Carol A. Kramer, Susanne M. Arnold. Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia intermedia. Int. J Radiation Oncology Biol. Phys. 1998; 42(3): 607-609.

Russo D, Pileri S, Barbieri E, Bandini G, Zaccaria A, Benfenati D, Bernardi B, Trevisan C, Busacca M, Babini L, etal. Spinal cord compression by extramedullary hematopoietic tissue in a thalassemic patient: prompt effect of radiotherapy. Haematologica. 1989 SepOct;74(5):495-8. Erratum in: Haematologica 1990 Mar-Apr; 75(2): following 201.

Papavasiliou C. Clinical expressions of the expansion of the bone marrow in the chronic anemias: the role of radiotherapy. Int J Radiat Oncol Biol Phys. 1994 Feb 1; 28(3): 605-12. Review.

Pistevou-Gompaki K, Skaragas G, Paraskevopoulos P, Kotsa K, Repanta E. Extramedullary haematopoiesis in thalassaemia: results of radiotherapy: a report of three patients. Clin Oncol (R Coll Radiol). 1996; 8(2): 120-2.

Munn RK, Kramer CA, Arnold SM. Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia intermedia. Int J Radiat Oncol Biol Phys. 1998 Oct 1; 42(3): 607-9.

Plataniotis G, Theofanopoulou M, PistevouGobaki K. Registration of symptomatic patients with extramedullary hemopoiesis masses, treated by radiotherapy. Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):280; author reply 280-1

N De Klippel, M F Dehou, C Bourgain, R Schots, J De Keyser and G Ebinger, Progressive paraparesis due to thoracic extramedullary hematopoiesis in myelofibrosis. Case report. J Neurosurg 79 (1993), pp. 125-127.

Alberti B, Patrikiou A, Terentiou A, Frangatou S, Papadimitriou A. Spinal cord compression due to extramedullary haematopoiesis in two patients with thalassemia: complete regression with blood transfusion therapy. J Neurol, 2001 Jan; 248 (1): 18-22

Saxon BR, Rees D, Olivieri NF. Regression of extramedullary haemopoiesis and augmentation of fetal haemoglobin concentration during hydroxyurea therapy in b-thalassaemia. BrJ Haematol 1998; 101: 416-9.

Cianciulli P, Caravita di Toritto T, Sorrentino F et al. Hydroxyurea therapy in paraparesis and cauda euqina syndrome due to extramedullary haematopoiesis in thalassaemia: improvement of clinical and haematological parameters. EurJ Haematol 2000; 64: 426-9.

Downloads

Published

2023-09-07

How to Cite

1.
SUWANNALAI T. SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS IN THALASSEMIA: EFFECTIVE RESULTS OF RADIOTHERAPY: A REPORT OF TWO PATIENTS AND REVIEW OF THE LITERATURE. ASEAN J Radiol [Internet]. 2023 Sep. 7 [cited 2024 Nov. 22];13(1):21-3. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/781

Issue

Section

Original Article

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.