Renal complication of crizotinib: Crizotinib-associated complex renal cyst

Warissara Jutidamrongphan; Pimporn Puttawibul

doi:10.46475/aseanjr.v21i1.67

Authors

Warissara Jutidamrongphan, M.D. The Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
Pimporn Puttawibul, M.D. The Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand

DOI:

https://doi.org/10.46475/aseanjr.v21i1.67

Keywords:

Crizotinib, Non-small cell lung cancer, Complex renal cyst, ALK inhibitor.

Abstract

Crizotinib is one of the first generations of tyrosine kinase inhibitors targeting anaplastic lymphoma kinase(ALK) and is recently found to be associated with the development of complex renal cysts with inconclusive explanation up to this time. Hereby, we discuss the hypothesis of Crizotinib-associated complex renal cyst development and coexisting renal impairment after initiation of the treatment in a 75-year-old man with ALK-positive non-small cell lung cancer whose complex renal cysts evolved after initiation and cessation of Crizotinib treatment. The coexistence as renal impairment persisted even after switching from Crizotinib to Ceritinib.

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