DETECTION OF INFLAMMATORY LESIONS WITH 99m Tc HMPAO LABELLED LEUKOCYTES

Authors

  • M. POSHYACHINDA Division of Nuclear Medicine, Department of Radiology, Chulalongkorn Hospital
  • S. MEKAREEYA Division of Nuclear Medicine, Department of Radiology, Chulalongkorn Hospital

Keywords:

Leukocytc imaging, Inflammatory lesion, Radionuclide imaging

Abstract

This study was undertaken to evaluate the usefulness of 99m. Tc HMPAO leukocyte imaging in the detection of inflammatory lesions. A group of 35 patients with suspected infection or inflammatory lesions was studied. Leukocytes from 45 millilitres of blood from each patient were labelled with Tc HMPAO. The mean labelling efficiency was 44%. After dynamic image, the static images were taken at 30-60 minute, 4 and 24 hour after injection of labelled leukocytes. Most of the positive scans were best seen at 4 hour and lasted till 24 hour. The overall sensitivity, specificity and accuracy was 92%, 95% and 94% respectively.
It is concluded that 99m Tc HMPAO leukocyted imaging is a very helpful diagnostic investigation for infection or inflammatory lesions.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Lavender JP, Lowe J, Bakere Jr, et al. Gallium citrate scanning in neoplastic and inflammatory lesions. Br J Radiol 1971: 44: 361-366.

Blair DC, Carrol M, Silva J, Fekety R. Localization of infectious processes with gallium citrate Ga67. JAMA 1974: 230; 82-85.

Hopkins GA, Kan M, Mendez CQ. Early67 Ga scintigraphy for the localization of abdominal abscesses. JNM 1975: 16; 990-992.

Kumar B, Coleman RE, Alderson PO. Gallium citrate (Ga) imaging in patients with suspected inflammatory processes. Arch Surg 1975: 110; 1237-1242.

McAfee JG, Thakur ML. Survey of radioactive agents for in vitro labelling of phagocytic leukocytes. J Nucl Med 1976: 17; 480-487.

Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW. Indium-111 labelled autologous leukocytes in man. J Nucl Med 1977: 18; 1014- 1021.

Knochel JQ, Koehler PR, Lee TG, Welch DM. Diagnosis of abdominal abscesses with computed tomography, ultrasound and In-111 leukocyte scans. Radiology 1980: 137; 425-432.

Coleman RE: Radiolabeled leukocytes. In Nuclear Medicine Annual 1982, Freeman LM, Weissmann H, eds., New York, Roven Press, pp. 119-141, 1982.

Peters AM, Saverymuttu SH, Reavy HJ, Danpure HJ, Osman S, Lavender JP. Imaging inflammation with 111-indium-tropolonate labelled leukocytes. J Nucl Med 1983: 24; 39-44.

Becker W, Fischbach W, Reiners C, Borner W. Three phase white blood cell scan: diagnostic validity in abdominal inflammatory diseases. J Nucl Med 1986: 27; 1109-1115.

m

Peters AM, Danpure HJ. Osman s, Hawker RJ, et al. Clinical experience with 99m. Tc-hexamethyl- propylene-amineoxime for labelling leukocytes and imaging inflammation. Lancet 1986: ii; 946-949.

Roddie ML, Peters AM, Danpure HJ, et al. Inflammation: Imaging with 99m Tc-HMPAO- labelled leukocytes. Radiology 1988: 166; 767-772.

Costa DC, Lui D, Ell PJ. White cells radiolabelled with 111 In and 99 Tcm- a study of relative sensitivity and in vivo viability. Nucl Med Commun 1988: 9; 725-731.

Vorne M, Soini I, Lantto T, Paakinen S. Technetium-99m HM-PAO-labeled leukocytes in detection of inflammatary lesions: Comparison with Gallium-67 citrate. J Nucl Med 1989: 30; 1332-1336.

Saverymuttu SH, Maltby P, Batman P, et al. False positive localization of indium-III granulocytes in colonic carcinoma. Br. J Radiol 1986: 59; 773-777.

Schmidt KG, Rosmussen JW, Wedebye IM, et al. Accumulation of indium-111-labeled granulocytes in malignant tumours. J Nucl Med 1988: 29; 479-484.

Gilbert BR, Gerqueira MD, Eary JF, et al. Indium-111 white blood cell scan for infectious complications of polycystic renal disease. J Nucl Med 1985: 26; 1283-1286.

Fortner A, Taylor A. Jr, Alazraki N, Datz FL. Advantage of Indium-111 leukocytes over ultrasound in imaging an infected renal cyst. J Nucl Med 1986: 27; 1147-1149.

Johnson JA, Routt ML, Christie MJ et al. Correlation of Indium-111 labeled leukocyte imaging and Technetium-99m skeletal scintigraphy in the evaluation of infected total hip prostheses. (Abst) J Nucl Med 1986: 27; 1800-1801.

Boubaker A, Bischof Delaloye A, Blanc CH, et al. Immunoscintigraphy with antigranulocyte monoclonal antibodies for the diagnosis of septic loosening of hip prostheses. Eur J Nucl Med 1995: 22; 139-147.

Larson EB, Featherstone HJ, Petersdorf RG. Fever of undetermined origin: diagnosis and follow-up of 105 cases; 1970-1980. Medicine 1982: 61; 269-292.

Downloads

Published

2023-03-30

How to Cite

1.
POSHYACHINDA M, MEKAREEYA S. DETECTION OF INFLAMMATORY LESIONS WITH 99m Tc HMPAO LABELLED LEUKOCYTES . ASEAN J Radiol [Internet]. 2023 Mar. 30 [cited 2024 Dec. 12];1(3):1-8. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/256

Issue

Section

Original Article

Similar Articles

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.