Acute changes of superior mesenteric artery pressure after intraarterial bolus injection of prostaglandin-E1.: Hemodynamics of prostaglandin-E1.

Yukihiro Hama

doi:10.46475/aseanjr.v24i2.206

Authors

Yukihiro Hama, M.D., Ph.D. Department of Radiology, Tokyo Edogawa Cancer Center, Edogawa Hospital, 2-24-18 Higashikoiwa, Edogawaku, Tokyo 133-0052, Japan.

DOI:

https://doi.org/10.46475/aseanjr.v24i2.206

Keywords:

Interventional radiology, Pharmacodynamics, Catheterization

Abstract

Background: A bolus injection of prostaglandin-E1 (PGE1) into the superior mesenteric artery (SMA) immediately before SMA-portography can effectively visualize the portal vein.

Objective: The purpose of this study was to obtain basic pharmacoangiographical data and evaluate the hemodynamic changes following intra-arterial bolus injection of PGE1.

Materials and Methods: Forty-four consecutive patients undergoing transcatheter arterial chemoembolization (TACE) for liver cancer were retrospectively evaluated. SMA-portography was performed prior to TACE. An intra-arterial bolus injection of PGE1 was performed immediately before SMA-portography. Both SMA pressure and left brachial artery pressure were measured before, 1, 2, 3, 4, and 5 minutes after SMA-portography.

Results: Systolic pressure in the SMA decreased significantly 3 minutes after SMA-portography and remained low for 5 minutes. The maximum reduction rates in systolic and diastolic blood pressure in the SMA were 4.8% (4 minutes after SMA-portography) and 6.8% (5 minutes after SMA-portography), respectively. The left brachial artery pressure decreased similarly to the SMA. There were no significant changes in pulse pressure before or after PGE1 injection in either the SMA or brachial arteries.

Conclusion: A bolus injection of PGE1 into the SMA was shown to decrease blood pressure in the SMA and brachial arteries, but the pulse pressure remained constant.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Redvanly RD, Chezmar JL. CT arterial portography: technique, indications and applications. Clin Radiol 1997;52:256-68. doi: 10.1016/s0009-9260(97)80051-7.

Soyer P. CT during arterial portography. Eur Radiol 1996;6:349-57. doi: 10.1007/BF00180609.

Owen NE. Effect of prostaglandin E1 on DNA synthesis in vascular smooth muscle cells. Am J Physiol. 1986 Apr;250(4 Pt 1):C584-8. doi: 10.1152/ajpcell.1986.250.4.C584.

Davidovic LB, Vranes MR, Lotina SI, Cernak IF, Velimirovic DB, Stojanov PL, et al. Intraarterial perfusion of prostaglandin E1 after lumbar sympathectomy or reconstruction on femoropopliteal segment. Int Angiol 1991;10:178-81.

Akkinapally S, Hundalani SG, Kulkarni M, Fernandes CJ, Cabrera AG, Shivanna B, et al. Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions. Cochrane Database Syst Rev 2018;2:CD011417. doi: 10.1002/14651858.CD011417.pub2.

Urciuoli R, Cantisani TA, Carlini M, Giuglietti M, Botti FM. Prostaglandin E1 for treatment of erectile dysfunction. Cochrane Database Syst Rev 2004;(2):CD001784. doi: 10.1002/14651858.CD001784.pub2.

Cacione DG, Macedo CR, do Carmo Novaes F, Baptista-Silva JC. Pharmacological treatment for Buerger's disease. Cochrane Database Syst Rev 2020;5:CD011033. doi: 10.1002/14651858.CD011033.pub4.

Ambrus JL, Taheri P, Killion D, Donaldson G. Clinical experience with prostaglandin E1 in the treatment of arteriosclerosis obliterans. A preliminary report. J Med 1983;14:1-15.

Miyata T, Yamada N, Miyachi Y. Efficacy by ulcer type and safety of lipo-PGE1 for Japanese patients with diabetic foot ulcers. J Atheroscler Thromb 2010;17:805-16. doi: 10.5551/jat.3608.