COMPARATIVE STUDY OF STANDARD FRACTIONATION AND REDUCED FRACTIONATION RADIOTHERAPY IN UTERINE CERVICAL CANCER.

Abstract

During the first of January 1998 to 30^th of September 2000, new uterine cervical cancer patients were double-blinded randomly devided into 2 groups to receive a daily radiation dose fraction of 200 cGy or 250 cGy. In the standard treatment group, 20 fractions of 200 cGy were given to the pelvis and 5 fractions of 200 cGy were given to the parametria in addition. Three more fractions were given to boost the parametrial doses in stage IIIB patients. In the reduced fractionation group 15 fractions were given for the whole pelvis and 4 fractions for the parametria. Two booster doses to the parametria were given in stage IIIB. Both groups were treated 5 fractions per week. Time-dosefraction calculation formular (TDF) was used to determine the number of fractions. Both groups were given intracavitary radiation with Cesium LDR machine 24-26 Gy by single insertion. Residual tumor, local recurrent tumor, metastasis and complication were compared by T-test evaluation with 95 % confidence interval. The study showed worse local control in the reduced fractionation group in stage IIIB patients. Better local control in the reduced fractionation group in stage IB patients. No significant SEPT. - DEC. 2001. Volume VII Number III difference was seen in the early and late complication of radiation of both groups.