KALLMANN SYNDROME: A CASE REPORT OF MRI FINDINGS.

Authors

  • Orasa CHAWALPARIT Department of Radiology, Siriraj Hospital, Faculty of Medicine, Mahidol University
  • Suthisuk SUTHIPONGCHAI Department of Radiology, Siriraj Hospital, Faculty of Medicine, Mahidol University

Abstract

The MRIfindings of a case of Kallmann syndrome was reported. A 16 years-old female patient came with a history of primary amenorrhea and hyposmia. The hormonal studies were shown as hypogonadotropic hypogonadism. The MRL.of olfactory region reveals absent of olfactory bulb and hypoplasia of the olfactory sulci. The imaging was shown and a review of literatures was presented.

Kallmann syndrome is a form of congenital hypogonadotropic hypogonadism with anosmia or hyposmia. The prevalence has been estimated to be one in 10,000 males and one in 50,000 females.? The MR imagings have been reported with absent or hypoplasia of the olfactory bulb and tract as well as hypoplasia of olfactory sulci. We reported one case of MR imaging with clinical suspected to be this disease in a girl, which is a rarer prevalence in the sex-distribution.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Franco B., Guioli S, Pragliola A, et al. A gene deleted in Kallmann syndrome shares homology with neural cell adhesion and axonal path-finding molecules. Nature 1991;353:529-536.

Jones JR, Kemmann E. Olfactogenital dysplasia in the female. Obstet Gynecol Annu 1976;5:443-466.

Kallmann FJ, Schoenfeld WA, Barrera SE. The genetic aspects of primary eunuchoidism. Am J Ment Defic 1944;48:203-206.

Klingmuller D, Dewes W, Krahe T, et al Magnetic resonance imaging of the brain in patients with anosmia and hypothalamic hypogonadism (Kallmann syndrome). J Clini Endocrinol Metab 1987:;65:58 1-584.

Schwanzel-Fukuda M, Bick D, Pfaff DW, Luteinizing hormone-releasing hormone (LHRH) expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Mol Brain Res 1989;6:311-326.

Truwit CL, Barkovich AJ, Melvin M, et al. MR imaging of Kallmann syndrome, a genetic disorder of neuronal migration affecting the olfactory and genital systems. AJNR 1993;14:827-838.

Downloads

Published

2023-04-11

How to Cite

1.
CHAWALPARIT O, SUTHIPONGCHAI S. KALLMANN SYNDROME: A CASE REPORT OF MRI FINDINGS. ASEAN J Radiol [Internet]. 2023 Apr. 11 [cited 2024 Nov. 21];5(3):285-7. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/501

Issue

Vol. 5 No. 3 (1999): September-December

Section

Original Article

License

Copyright (c) 2023 The ASEAN Journal of Radiology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Disclosure Forms and Copyright Agreements
All authors listed on the manuscript must complete both the electronic copyright agreement. (in the case of acceptance)

Most read articles by the same author(s)