TREATMENT OF COLORECTAL CANCER A MALAYSIAN EXPERIENCE

Authors

  • G.C.C. Lim Institute of Radiotherapy and Oncology, Hospital Kuala Lumpur
  • I. Fuad Institute of Radiotherapy and Oncology, Hospital Kuala Lumpur
  • K.G. Rampal Department of Community Health, Faculty of Medicine, Universiti Kebangsaan
  • A.K.H. Lim Institute of Radiotherapy and Oncology, Hospital Kuala Lumpur

Keywords:

colorectal cancer, epidemiology, radiotherapy, chemotherapy, recurrence, crude survival

Abstract

Three hundred and twenty patients with colorectal cancer who had undergone treat- ment in the Institute of Radiotherapy and Oncology, Hospital Kuala Lumpur between 1986 and 1994 were analysed. Patients with tumours of the rectum or rectosigmoid colon made up the largest group (62.5%). Dukes' A disease (1.9%) appeared to be underrepresented while the proportion of patients (11.6%) under the age of 40 years was higher than other studies. The largest racial group in this series was Chinese (61.9%).
Treatment with surgery, radiotherapy and chemotherapy together with the difficulties involved was discussed. The highlights were the lack of serious toxicity of chemotherapy even when used in combination with radiotherapy. The patterns of treatment have been influenced largely by the late stage at presentation, the practical considerations in the popu- lation as well as the available resources.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Chan CK, Singh J, Rasid BK, Devaraj T. Penang cancer cases reported to the National Cancer Registry of Malaysia, 1987 - 1990: An epidemiological analysis. Med J of Malaysia. 1994;49(2):122-131.

Lim AKH, Lim GCC. Burden of advanced cancer in Malaysia. Proceedings of the National Hospice Conference, Penang. 1993;13-18.

Gastrointestinal Tumor Study Group. Prolon gation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med. 1985:312:1465-1472.

Gastrointestinal Tumor Study Group. Survival after postoperative combination treatment of rectal cancer. N Engl J Med. 1986;315:1294-1295.

Krook JE, Moertel CG, Gunderson LL. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med. 1991;324:709-715.

Gerard A, Buyse M. Nordlinger B. Preo- perative radiotherapy as adjuvant treatment in rectal cancer: Final results of a randomi- zed study of the European Organization on Research and Treatment of Cancer Gas- trointestinal Tract Cancer Co-operative Group. Ann Surg. 1988;208:606-614.

Moertel CG, Fleming TH, Macdonald JS. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990;322:352-358.

O'Connell M, Maillard J, Macdonald J. An Intergroup trial of intensive course 5-FU and low dose leucovorin as surgical adjuvant therapy for high risk colon cancer [abstract]. Proc ASCO. 1993;12:552.

Moertel C, Fleming T, Macdonald J, Haller D, Laurie J. The Intergroup study of fluorou- racil plus levamisole and levamisole alone as adjuvant therapy for stage C colon cancer: A final report [abstract]. Proc Am Soc Clin Oncol. 1992;11:161.

Gunderson LL, Martin KJ, O'Connell MJ, Beart RW, Kvols LK, Nagorney DM. Residual, recurrent or unresectable gastroin- testinal cancer. Role of radiation in single or combined modality treatment. Cancer. 1985;- 55:2250-2258.

Dukes CE. The classification of cancer of the rectum. J Pathol. Bacteriol. 1932:35:323-332.

Miller AB, Hoogstraten B, Staquet M. Winkler A. Reporting results of cancer treatment. Cancer. 1981;47:207-214.

Zubrod CG, Schneiderman M, Frei E, et al. Appraisal of methods for the study of chemo- therapy of cancer in man: comparative thera- peutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chronic Dis. 1960;11:7-33.

Ohman U. Colorectal carcinoma in patients less than 40 years of age. Dis Colon Rec- tum. 1982;-25:209-214.

Dayal Y, DeLellis RA. The gastrointestinal tract. In: Cotran RS, Kumar V. Robbins SL. (eds). Robbins Pathologic Basis of Disease. 4th edition. Philadelphia: WB Saunders, 1989;- 18:898.

Arnott S. Gastrointestinal tract. In: Sikora K, Halnan KE (eds). Treatment of cancer. London: Chapman and Hall, 1990:485.

Lockhart-Mummery HE, Ritchie JK, Hawley PR. The results of treatment for cancer of the rectum at St. Mark's Hospital from 1948-1972. Br J Surg. 1976;63:673-677.

Goh HS, Ti TK, Rauff A. Foong WC. Lee YS. Colorectal cancer in Singapore: Prelimi- nary report of the colorectal cancer project from the University Department of Surgery, NUS. Singapore Med J. 1985;26(1):65-72.

Cohen AM, Minsky BD,Schilsky RL. Colon cancer. In: De Vita VTJr. Hellman S. Rosen- berg SA (eds). Cancer: Principles and practice of oncology. Philadelphia: JB Lippincott, 1993:30:937.

Downloads

Published

2023-04-06

How to Cite

1.
Lim G, Fuad I, Rampal K, Lim A. TREATMENT OF COLORECTAL CANCER A MALAYSIAN EXPERIENCE. ASEAN J Radiol [Internet]. 2023 Apr. 6 [cited 2024 Nov. 22];3(1):105-12. Available from: https://asean-journal-radiology.org/index.php/ajr/article/view/369

Issue

Section

Original Article

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.