OSTEOSARCOMA WITH HIGH SERUM ALKALINE PHOSPHATASE OVER 500 U/L
Abstract
Twenty two cases of primary osteosarcoma of the bone out of 125 total cases (17.6%) were detected to have over 500 U/L of serum alkaline phosphatase level (AP), which was a very high level as compared to the normal range of 40-105 U/L. There were 13 cases (59.09%) with metastatic disease or terminated by other courses. Only two patients in this group still survive more than 86 and 17 months. Their initial AP were not the highest. The level gradually increased after intraarterial chemotherapy and suddenly turned to normal level after radiation and surgery of the primary bone tumor. In the group of 32 long term survivors among the 125 cases, 13 cases had normal range of AP, only 2 cases had AP over 400 IU. This study, we concluded that if initial serum alkaline phosphatase was over 500 U/L, the disease was more aggressive and tended to metastasize. So different approaches in this group of patients may lead to longer survival.
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